Analysis Overview

The following analyses were run adjusted for baseline age and sex. Baseline models adjusted for cohort using A4 vs LEARN/SF, while longitudinal models adjusted for cohort using A4 Placebo vs A4 Treated vs LEARN/SF. All PACC models are additionally adjusted for education, and longitudinal PACC models are additionally adjusted for PACC version and cumulative dose. p-tau217 models additionally adjusted for BMI.

Models highlighted in orange yielded significant results after FDR correction.

1. Baseline PACC

2. Baseline Amyloid

3. Baseline MTL Tau

4. Baseline NEO Tau

5. Baseline p-tau217

6. Longitudinal PACC

7. Longitudinal Amyloid

8. Longitudinal MTL Tau

9. Longitudinal NEO Tau

10. Longitudinal p-tau217