Analysis Overview

The following analyses were run adjusted for baseline age and sex. Baseline models adjusted for cohort using A4 vs LEARN/SF, while longitudinal models adjusted for cohort using A4 Placebo vs A4 Treated vs LEARN/SF. All PACC models are additionally adjusted for education, and longitudinal PACC models are additionally adjusted for PACC version and cumulative dose. p-tau217 models additionally adjusted for BMI.

Models highlighted in orange yielded significant results after FDR correction.

1. Baseline PACC

• PACC ~ Gene
• PACC ~ Gene x Sex
• PACC ~ Gene x E4
• PACC ~ Gene x Sex x E4
• PACC ~ Gene x Amyloid
• PACC ~ Gene x Sex x Amyloid

2. Baseline Amyloid

• Amyloid ~ Gene
• Amyloid ~ Gene x Sex
• Amyloid ~ Gene x E4
• Amyloid ~ Gene x Sex x E4

3. Baseline MTL Tau

• MTL ~ Gene
• MTL ~ Gene x Sex
• MTL ~ Gene x E4
• MTL ~ Gene x Sex x E4
• MTL ~ Gene x Amyloid
• MTL ~ Gene x Sex x Amyloid

4. Baseline NEO Tau

• NEO ~ Gene
• NEO ~ Gene x Sex
• NEO ~ Gene x E4
• NEO ~ Gene x Sex x E4
• NEO ~ Gene x Amyloid
• NEO ~ Gene x Sex x Amyloid

5. Baseline p-tau217

• p-tau217 ~ Gene
• p-tau217 ~ Gene x Sex
  
• p-tau217 ~ Gene x E4
• p-tau217 ~ Gene x Sex x E4
• p-tau217 ~ Gene x Ab
• p-tau217 ~ Gene x Sex x Ab

6. Longitudinal PACC

• PACC ~ Gene
• PACC ~ Gene x Sex
• PACC ~ Gene x E4
• PACC ~ Gene x Sex x E4
• PACC ~ Gene x Ab
• PACC ~ Gene x Sex x Ab
• PACC ~ Gene x p-tau217

7. Longitudinal Amyloid

• Amyloid ~ Gene
• Amyloid ~ Gene x Sex
• Amyloid ~ Gene x E4
• Amyloid ~ Gene x Sex x E4

8. Longitudinal MTL Tau

• MTL ~ Gene
• MTL ~ Gene x Sex
• MTL ~ Gene x E4
• MTL ~ Gene x Sex x E4
• MTL ~ Gene x Amyloid
• MTL ~ Gene x Sex x Amyloid

9. Longitudinal NEO Tau

• NEO ~ Gene
• NEO ~ Gene x Sex
• NEO ~ Gene x E4
• NEO ~ Gene x Sex x E4
• NEO ~ Gene x Amyloid
• NEO ~ Gene x Sex x Amyloid

10. Longitudinal p-tau217

• p-tau217 ~ Gene
• p-tau217 ~ Gene x Sex
• p-tau217 ~ Gene x E4
• p-tau217 ~ Gene x Sex x E4
• p-tau217 ~ Gene x Amyloid
• p-tau217 ~ Gene x Sex x Amyloid